![]() There does not appear to be additional benefit for extending temozolomide beyond 6 months. The optimal duration of temozolomide has not yet been established. This is the lone predictive marker that has been established thus far in the treatment of glioblastoma. The molecular O6-methylguanine-DNA-methyltransferase marker predicts a greater likelihood of deriving benefit from temozolomide therapy. Genetic factors may also be helpful in guiding therapy. ![]() Metabolic imaging modalities are also available, such as positron emission tomography scans and spectroscopy. Imaging with MRI may provide insight into tumor burden, as well as patterns of growth and potential deficits that the patient may be facing. There are several tumor testing options that can help to guide initial treatment for patients with glioblastoma. Tumor treating fields have also been incorporated into the treatment guidelines for patients with supratentorial disease as a class 2A recommendation in the adjuvant setting and a class 2B recommendation for recurrent disease. 4,5 Temozolomide is also commonly administered as part of treatment protocols for patients with glioblastoma. After surgery, fractionated external beam radiation therapy is used as a standard therapy based upon early studies. 2,3 Gross total removal of these infiltrative tumors is especially challenging, given the need to preserve patient functioning as much as possible. 1 The current standard for patients with newly diagnosed glioblastoma begins with maximal safe surgical resection if feasible, with previous studies showing the efficacy of resection for survival outcomes, particularly those with good performance status (PS). Initial Treatment Options in GlioblastomaĬlinical outcomes for patients with glioblastoma remain ominous, with less than one-third of patients surviving beyond 1 year and less than 5% surviving 5 years out. Participants may immediately download a CME/CE certificate upon completion of these steps. Complete the posttest and pass with a score of 70% or higher, complete the evaluation and then click on request for credit. ![]()
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